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Review rounds up the mechanisms and drug evidence behind vascular calcification
AI-assisted summary Written by WellCareChina with AI assistance and checked against the original article.
A review in Signal Transduction and Targeted Therapy on 2 October 2026 surveys vascular calcification, the deposition of calcium-based mineral in artery walls that is linked to higher cardiovascular risk. The authors describe it as an actively regulated process driven by changes in vascular smooth-muscle cells, inflammation, oxidative stress and other pathways, and they review what clinical trials have reported for candidate drugs including phosphate binders, bisphosphonates, SGLT2 inhibitors and vitamin K. The review concludes that these pathways overlap and that understanding them better is needed to develop more precise treatments.
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Source tier A — open-access review (CC BY-NC-ND 4.0; no translation); our own summary and a link back to the original, no full-text copy.